#701 – Amazon Advertising: AI vs. Rules Carrie Miller , Carrie Miller, Principal Brand Evangelist at Helium 10 3 minute read Published: September 16, 2025 Share: URL copied Curious about how AI and Rules can revolutionize your Amazon advertising strategy? Imagine harnessing the power of emerging AI tools to supercharge your PPC campaigns and keep your brand ahead of the competition. Join us as Destaney Wishon shares her expertise on striking the perfect balance between AI, automation, and rule-based approaches to unlock the full potential of your Amazon advertising efforts. Our conversation takes an insightful turn as we explore the complexities of managing advertising campaigns for brands with intricate SKU lines and varied objectives. Destaney unpacks the nuances of using AI and rules-based systems, revealing how to leverage these tools without losing sight of your brand’s unique insights and goals. We get into the importance of contextual understanding when evaluating key metrics like ACoS, ensuring that your strategies align with your specific product types and campaign goals. Plus, uncover the trade-offs between automation and manual control, and learn how agencies can enhance operational efficiency while maintaining that all-important personal touch. But that’s not all. We offer a comprehensive guide to optimizing your advertising strategies with Amazon Marketing Cloud (AMC) and audience targeting techniques. You’ll learn how to use Helium 10 Ads to set up AMC instances and discover practical tips for building profitable audience segments. From increasing your Return on Advertising Spend (ROAS) to avoiding campaign cannibalization, we equip you with the tools and insights necessary to thrive in a competitive Amazon marketplace. To top it off, we invite you to subscribe to the Serious Sellers Podcast’s new YouTube channel for a chance to win a one-on-one session with either Carrie, Bradley, or Shivali, offering personal insights and a unique opportunity to enhance your advertising game. In episode 701 of the Serious Sellers Podcast, Carrie and Destaney discuss: 00:59 – AI vs Automation in Amazon Advertising 06:47 – Optimizing AI for Different Goals 09:30 – Advanced Strategies for Amazon Advertising 10:14 – Interpreting ACoS for Amazon PPC Success 15:53 – AI vs. Keyword Harvesting in Marketing 18:38 – Importance of Video in Amazon Advertising 22:37 – Strategies for Amazon Ad Console 31:23 – Optimizing PPC Campaigns for Improved ROAS 34:24 – Engagement Incentives for Video Viewers Enjoy this episode? Be sure to check out our previous episodes for even more content to propel you to Amazon FBA Seller success! And don’t forget to “Like” our Facebook page and subscribe to the podcast on iTunes, Spotify, or wherever you listen to our podcast. Get snippets from all episodes by following us on Instagram at @SeriousSellersPodcast Want to absolutely start crushing it on Amazon? Here are few carefully curated resources to get you started: Freedom Ticket: Taught by Amazon thought leader Kevin King, get A-Z Amazon strategies and techniques for establishing and solidifying your business. Helium 10: 30+ software tools to boost your entire sales pipeline from product research to customer communication and Amazon refund automation. Make running a successful Amazon or Walmart business easier with better data and insights. See what our customers have to say. Helium 10 Chrome Extension: Verify your Amazon product idea and validate how lucrative it can be with over a dozen data metrics and profitability estimation. 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Subscribe: Carrie Miller , Carrie Miller, Principal Brand Evangelist at Helium 10 A 7-figure e-commerce seller, Carrie began her journey on Amazon, expanding rapidly to Shopify and now Walmart.com. Currently serving as the Principal Brand Evangelist for Walmart.com tools at Helium 10, she's deeply passionate about sharing success strategies, tips, and tricks with fellow e-commerce sellers. Published in: Serious Sellers Podcast Share: URL copied Share: Published in: Serious Sellers Podcast Thought Leadership, Tips, and Tricks Never miss insights into the Amazon selling space by signing up for our email list! Subscribe Achieve More Results in Less Time Accelerate the Growth of Your Business, Brand or Agency Maximize your results and drive success faster with Helium 10’s full suite of Amazon and Walmart solutions. Get Started